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Immunity to commensal papillomaviruses protects against skin cancer. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. PrP antibodies do not trigger mouse hippocampal neuron apoptosis.

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Due to the SCID mutation, the success ratio of human tumor transplantation is very high even higher than nude micewhich makes them into jacksson valuable immunodeficient animal model for testing new cancer treatments, for example [ 11 ], and as hosts for human immune system tissues. Courtesy of The Jackson Laboratory Variation among mouse models Differences exist among the various mouse models and it jackon important to be aware of this variation.

Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Infect Immun.

Machine learning of toxicological big data enables read-across structure activity relationships RASAR outperforming animal test reproducibility. Nat Immunol.

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Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Lobund-Wistar rat. J Neurogenet. More than 11, strains of mice are available from The Jackson Laboratory.


A conditional knockout resource for the genome-wide study of mouse gene function. Electrical and synaptic integration of glioma into neural circuits. Hauschka to create spp fertile mouse line. Many such transgenic lines are then used for the in vivo javkson just mentioned. It also maintains an integrated mouse information resource. Harlan Laboratories Its famed breeding facility, Sprague-Dawley farm in Madison, Wisconsin, where the namesake rat strain, Sprague Dawley rat, was initially bred, is now part of Harlan.

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Regenerative potential of prostate luminal cells revealed by single-cell analysis. Frontal cortex neuron types categorically encode single decision variables. Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. Regulation of lifespan by neural excitation and REST.

Enhancing mucosal immunity by transient microbiota depletion. Phycotoxicity of linear alkylbenzene sulfonate.

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An overlapping protein-coding region in influenza A virus segment 3 modulates the host response. MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment. Lepr db-3J mice are "obese, hyperphagic, cold intolerant, insulin resistant, and infertile". Nackson mouse. Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair.

Kessler JD et al demonstrated that Myc-dependent cancer needs SUMOylation for tumorigenesis by performing breast cancer cell line xenografts using Harlan Labs female athymic nude Foxn1-nu mice [ 73 ]. Figure 5. Dense connectomic reconstruction in layer 4 of the somatosensory cortex. Dismantling the Papez circuit for memory in rats.

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ICR mice are a general-purpose model, used in particular in toxicology, neurobiology, oncology, epidemiology, hude, pharmacology, and also in product safety testing. Sci al. Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome.